Home Soft tissue infections Cellulitis



Cellulitis is an acute bacterial infection of the dermis and the subcutaneous tissue that most commonly affects the lower extremities, although it can affect other areas. It causes local signs of inflammation, such as warmth, erythema, pain, lymphangitis, and frequently systemic upset with fever and raised white blood cell count

One of the following oral antibiotics
Cephalexin 500 mg 6-hourly
Amoxicillin-clavulanate 1,2 gr 8-hourly
Levofloxacin 750 mg 24-hourly
In patients needing intravenous administration
One of following antibiotics
Cefazolin 2 g-8 hourly
Amoxicillin-clavulanate 1,2-2,2 gr 8-hourly
Levofloxacin 750 mg 24-hourly

In patients at risk for CA-MRSA or who do not respond to first line therapy consider anti- MRSA antibiotics

Oral options:
Minocycline100 mg 12-hourly
Trimethoprim and sulfamethoxazole 160/800 mg 12-hourly
Doxycycline 100 mg 12-hourly
Clindamycin 300–600 mg 8-hourly (high resistance rate)
Linezolid 600 mg 12-hourly
Tedizolid 200 mg 24-hourly

Intravenous options:
Vancomycin 25–30 mg/kg loading dose then 15–20 mg/kg/dose 8-hourly
Teicoplanin LD 12 mg/kg 12-hourly for 3 doses, then 6 mg/kg 12-hourly
Tigecycline 100 mg as a single dose, then 50 mg 12-hourly
Linezolid 600 mg 12-hourly
Daptomycin 4–6 mg/kg 24-hourly
Ceftaroline 600 mg 12-hourly
Dalbavancin 1000 mg once followed by 500 mg after 1 week or 1500 mg one dose
Tedizolid 200 mg 24-hourly
Televancin 10 mg/kg 24-hourly